Funding to investigate treatment for obesity-related illnessesPalo Alto, Calif. – The Palo Alto Medical Foundation’s (PAMF’s)
Research Institute has received grants totaling nearly $5 million, including a five-year, $4 million grant from the National Heart Lung and Blood Institute to study the relationship between obesity and asthma and a three-year, $800,000 grant from the National Institute of Diabetes and Digestive and Kidney Diseases and American Heart Association to study the effectiveness of lifestyle intervention strategies in primary care to prevent overweight or obese individuals with pre-diabetes from developing diabetes.
“Chronic diseases, such as diabetes and asthma, have increased in prevalence and had a significant impact on people’s overall health, as well as health care costs in this country," said
Sandra Wilson, Ph.D., chair of the Department of Health Services Research at the PAMF Research Institute. “Both of these studies will help to determine whether theories about weight loss and controlling asthma; and lifestyle interventions in the prevention of diabetes are backed by scientific evidence. They have the potential to help patients better manage their conditions and change the treatment guidelines and protocols for these chronic illnesses.”
Obesity and Asthma StudyPAMF will collaborate with researchers from Kaiser Permanente, Stanford, Harvard, and Oregon Health & Science University to study whether weight loss, in addition to improving overall health, also improves control of asthma. In the United States, the prevalence of obesity has doubled in adults and approximately tripled in children and adolescents since 1980. The latest population surveys have found that two-thirds of U.S. adults and one in six children and adolescents are overweight or obese. At the same time, the prevalence of asthma has increased significantly. Obesity may directly cause or worsen asthma through its effects on lung function, systemic inflammation, and/or other bio-physiological mechanisms. While asthma is often mistakenly viewed as a disease that only originates in childhood, compared with normal-weight adults, asthma incidence increases by an average of 38 percent in overweight and 92 percent in obese adults.
“We know that weight loss reduces the risk of several other major obesity comorbidities such as diabetes and hypertension, but this will be the first study of an evidence-based, state-of-the-art, lifestyle approach to weight loss in improving asthma outcomes for obese patients who also have asthma,” said
Jun Ma, M.D., Ph.D., associate scientist and investigator at the PAMF Research Institute. “While the clinical treatment of asthma should continue to emphasize proven pharmacological and patient self-management strategies, the available evidence is already sufficient to warrant the investigation of including evidence-based weight loss strategies as an additional treatment strategy for obese asthma patients.
“If we can establish the benefits of weight loss in the treatment of obese asthma patients, we have the chance to positively impact the health of many people and develop clear clinical guidelines for providers.”
Effectiveness of Lifestyle Interventions on Pre-Diabetic Patients in Primary Care StudyThis three-year study conducted in coordination with PAMF’s
Los Altos Center will evaluate the acceptability, feasibility and potential effectiveness of translating an evidence-based weight reduction program for preventing or delaying the onset of type 2 diabetes to ongoing primary care of overweight or obese adults with pre-diabetes. About two-thirds of U.S. adults are overweight or obese, and 57 million people are estimated to have pre-diabetes – a condition characterized by blood glucose levels that are higher than normal but not yet high enough to be diagnosed as diabetes. Many of these individuals also have co-existing cardiovascular risk factors, such as abdominal obesity, dyslipidemia, and hypertension.
“Preventive health care is a major goal in primary care, but prevention of obesity and the management of associated risk factors in primary care settings has thus far been lagging substantially behind the evidence on effective treatment strategies for these conditions,” said Dr. Ma. “This study will examine whether proven, cost effective, lifestyle weight reduction models can be delivered successfully in a primary care setting and what impact this has on health outcomes.”
Research has demonstrated that intensive lifestyle interventions focusing on diet, physical activity and behavioral self-management, can help patients lose weight and delay or prevent the onset of type 2 diabetes. Face-to-face, individual counseling has proven to be one effective tool to help patients sustain their behavior changes and weight loss. However, the substantial resources required for sustained, one-on-one counseling are a barrier to widespread implementation. This trial will examine Internet-based assistance for patients and Internet-based assistance combined with individualized counseling by a dietician and exercise specialist in comparison to the usual care being provided now in primary care.
“We need to determine whether what we believe to be successful weight loss methods can be translated into routine clinical care on a much broader scale, both efficiently and cost effectively. The results of our study could help shape future primary care-based models of obesity management for the prevention of diabetes and cardiovascular disease,” said Dr. Ma.
For more information, contact:
Ben Drew
Public Affairs
Palo Alto Medical Foundation
650-691-6228
drewb1@pamf.org